THE ACTIVITY OF XANTHINE OXIDASE IN PLASMA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: THE RELATIONSHIP BETWEEN HYPERURICEMIA, INSULIN RESISTANCE, AND LIVER DYSFUNCTION

We aimed to investigate the clinical implication of plasma xanthine oxidase (XO) activity in patients with type 2 diabetes mellitus (DM). Materials and methods. 127 were examined for DM (72 female 55 male). Serum biochemical variables include aspartate aminotransferase (AST), alanine (ALT), fasting (FPG) postprandial (PPG) glucose, glycohemoglobin A1c (HbA1c), total cholesterol, triglyceride, high‐density lipoprotein low‐density creatinine (Cre) serum urine acid (SUA) was measured a conventional automated analyzer. The level insulin (IRI) determined by immuno-chemiluminescent method. Homeostasis model assessment resistance (IR) (HOMA-IR) index calculated formula: HOMA-IR=fasting (μmol/L)×FPG(mmol/L)/22.5. XO photometric rate glomerular filtration (eGFR) according CKD-EPI formulas. All statistical analyses performed using STATISTICA software version 10.0. Results. lnXO correlated IRI (rs=0.52; P<0.001) HOMA‐IR (rs=0.51; P<0.002). In addition, BMI (rs=0.40; P<0.001). contrast, not age (rs=-0.07; P=0.61), HbA1c (rs=-0.11; P=0.41), FPG (rs=-0,4; P=0.74) PPG (rs=-0.09; P=0.57). indices liver dysfunction or parameters closely related SUA DM: lnALT (rs=0.73; P<0.001), lnAST (rs=0.69; ALT/AST (rs=0.85; Cre (rs=-0.15; P=0.46) eGFR (rs=0.13; P=0.34). series multiple regression analyses, used as dependent variable, age, BMI, HbA1c, SUA, eGFR, lnAST, lnALT, IRI, HOMA-IR explanatory carried out. When variables, value (Model 1) an independent strong factor determining (R2=95.3%; P<0.00001). 2) also (R2=97.2%; without functions, 3) (R2=97.3%; These data suggest that values ALT HOMA-IR, marker hepatic IR, might be factors directly influencing DM. Conclusions. significantly mellitus. homeostatic (HOMA-IR), resistance,